Periodically we highlight the research accomplishments of members of our Section of General Thoracic Surgery, as their data become available. We will ask key simple but important questions including how they chose their research questions and most importantly how their work will impact patients.
Dr. Lisa Brown and co-authors’ paper Recurrence and Survival After Segmentectomy in Patients With Prior Lung Resection for Early-Stage Non-Small Cell Lung Cancer, was recently published first on line by the Annals of Thoracic Surgery. The work was originally presented at the Sixty-second Annual Meeting of the Southern Thoracic Surgical Association, Orlando, FL, November, 2015.
Dr. Brown is an Assistant Professor of Clinical Surgery, and the Clinical Director of the UC Davis Comprehensive Lung Cancer Screening Program.
What is the question in this study?
The goal of this study was to compare recurrence and survival in patients undergoing segmentectomy (or removal of a small part of the lung) for primary non-small cell lung cancer (NSCLC) versus those undergoing the same type of surgery for a second primary (completely new) NSCLC.
Why did you choose this research question?
We chose this research question because we were seeing many patients who had a prior lung surgery for NSCLC presenting with a second primary (completely new) NSCLC and there is minimal data on the optimal extent of removal of lung tissue for these patients. We were interested in determining whether the long-term outcomes after segmentectomy for second primary NSCLC were as good as or at least equal to those with primary NSCLC.
What were your findings?
In a series of 91 segmentectomies (23%) were undergoing segmentectomy for a second primary NSCLC and 70 (77%) were undergoing segmentectomy for a primary NSCLC (first lung cancer). The recurrence free survival was 61% in those undergoing segmentectomy for a second primary NSCLC and 84% in those undergoing segmentectomy for a first primary NSCLC (p=0.09). The 5-year survival was 55% in those with second primary NSCLC and 65% in those with primary NSCLC (p=0.4).
How might the findings help patients?
We concluded that segmentectomy is a reasonable resection strategy for patients with a second primary NSCLC as the long term survival is similar to those with primary NSCLC and lung tissue is preserved when compared to lobectomy.